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MYP_048663
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Basic Information
Ascaphin-2
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antibiotic activity
Antimicrobial ▸ Antifungal
Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Defense peptide
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Standard
24 amino acids
C116H190N34O30
Standard
Sequence
GFRDVLKGAAKQFVKTVAGHIANI
Physicochemical Analysis
2540.96 Da
10.29
2.85
2.59
0.1186
0.27
0.72
0.14
41.10
101.67
0.0833
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1044.97
-9.27
36.0
34.0
86.0
180.0
3.0
25.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0218690 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
RECORD: Rec_0240354 VERIFIED: YES
Provenance & Taxonomy
Amphibia [Animal]
8292
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
PMID15207717 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15207717/
RECORD: Rec_0246435 VERIFIED: YES
Provenance & Taxonomy
Ascaphus truei [Animal]
Ascaphin
Structure & Mods
ribosomal mature linear peptide [Linear]
Gene-encoded natural peptide composed of standard L-amino acids [L]
Bio-Activity Profile
Antimicrobial Antibacterial
PaperJ.M. Conlon et al. / Biochemical and Biophysical Research Communications 320 (2004) 170-175. The ascaphins: a family of antimicrobial peptides from the skin secretions of the most primitive extant frog, Ascaphus truei Evidence URLhttps://www.uniprot.org/uniprotkb/P0CJ26/entry
RECORD: Rec_0277139 VERIFIED: NO
Provenance & Taxonomy
Ascaphus truei [Animal]
Ascaphin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal
PMID15207717 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15207717/
RECORD: Rec_0376440 VERIFIED: YES
Provenance & Taxonomy
Ascaphus truei [Animal]
Structure & Mods
topology not specified [Not included yet]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-negative
PaperPubMed PMID: 15207717 PMID15207717 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15207717/
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