Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length430 amino acids

Chemical FormulaC2115H3296N536O619S15

DescriptionStandard

        MLSLLILLLNLTNHAFGQNPAIKAILTNKGLQYGSHIGADWMQEKIGSVIIPDVSGGVDIGIGTVHYVLDGISVSGCDVPEPSVEFYEGVGLKAVISGLSISMSGNWHTRFGIITDGGSFDLAVFNVDVTSVVQIGSDQSGHISISSKNCDAKVGEASINFHGGARYICPLVEEHVTDLERHLAEMQVSFKVNSALVLDVPLTNSPLVDSISLGLDLKGEFYSVQSHTDPPFKAEPFHLAEDKGHMLSLGLSEFTVNSASYAYFSAGLLQAQINDSMIPKASPFRLNTTSFGPLIPQLPKLFPNMLMELQVYARDVPMFSFQADKVTMEFPGAVKAFAIQPNASRTPLFKLNVDSIFSGMIRISEEKLNGLVELSNFTLTLASSEVGTFQVGFTLNYWFLFVAAKLEEGIVLPTMHHIHLVNPALKIQQV
    

Molecular Weight46616.99 Da

Isoelectric Point (pI)5.24

Net Charge (pH 7.0)-15.25

Net Charge (pH 7.4) -16.31

Charge Density (pH 7.0) -0.0355

GRAVY Index0.23

Hydrophobic Moment 0.62

Boman Index0.21

Instability Index30.96

Aliphatic Index 102.21

Aromaticity 0.0884

Extinction Coeff. Reduced 29910.00

Extinction Coeff. Oxidized 30035.00

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Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0208362 VERIFIED: NO

Provenance & Taxonomy

OrganismOncorhynchus tshawytscha [Animal]

FamilyBPI

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin

TargetGram-negative bacteria

MethodQualitative functional evidence