Peptide Database

Peptide NameHuman Defensin-5, HD5 [T7R,E21R]

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic

Standard StatusStandard

Sequence Length32 amino acids

Chemical FormulaC147H254N56O42S6

DescriptionStandard

        ATCYCRRGRCATRESLSGVCRISGRLYRLCCR
    

Molecular Weight3670.33 Da

Isoelectric Point (pI)9.80

Net Charge (pH 7.0)6.74

Net Charge (pH 7.4) 6.46

Charge Density (pH 7.0) 0.2105

GRAVY Index-0.26

Hydrophobic Moment 0.79

Boman Index-0.34

Instability Index25.67

Aliphatic Index 64.06

Aromaticity 0.0625

Extinction Coeff. Reduced 2980.00

Extinction Coeff. Oxidized 3355.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1639.53

LogP -21.61

H-bond Donors 71.0

H-bond Acceptors 55.0

Rotatable Bonds 122.0

Heavy Atoms 251.0

Ring Count 2.0

Amide Bonds 31.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0027156 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilyDefensin

Tax ID32630

Structure & Mods

Configsynthetic linear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

TargetEscherichia coli ATCC 25922

Activity0.8

MethodLD50

RECORD: Rec_0143081 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilyDefensin

Tax ID32630

Structure & Mods

Configsynthetic linear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

TargetEscherichia coli ATCC 25922

Activity1.8±0.4 μg/mL

RECORD: Rec_0213190 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilyDefensin

Tax ID32630

Structure & Mods

Configsynthetic linear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

TargetStaphylococcus aureus ATCC 25923

Activity0.39 μg/mL

MethodLD50

RECORD: Rec_0231467 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilyDefensin

Tax ID32630

Structure & Mods

Configsynthetic linear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Hemolytic

TargetMouse erythrocytes

Activity100 μg/mL

MethodHemolysis

RECORD: Rec_0355798 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilyDefensin

Tax ID32630

Structure & Mods

Configsynthetic linear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

TargetStaphylococcus aureus ATCC 25923

Activity1.4±0.3 μg/mL