Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length135 amino acids

Chemical FormulaC683H1077N185O183S6

DescriptionStandard

        QLQERYPDQPMELHLWARQQPLLSCHPDALHGTLFSSAEAFVVLPNTTRVPAFLLNIDANVTGKPTITRNRLGGTVRLTGLVPDPELAWTPLPVLCWAQGLPVPQVKRLETLLKFGLWLFGVPRANSKCCPCEVP
    

Molecular Weight15000.38 Da

Isoelectric Point (pI)8.40

Net Charge (pH 7.0)1.99

Net Charge (pH 7.4) 1.54

Charge Density (pH 7.0) 0.0147

GRAVY Index0.01

Hydrophobic Moment 0.54

Boman Index0.11

Instability Index45.56

Aliphatic Index 99.63

Aromaticity 0.0741

Extinction Coeff. Reduced 23490.00

Extinction Coeff. Oxidized 23740.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 5764.09

LogP -46.91

H-bond Donors 197.0

H-bond Acceptors 194.0

Rotatable Bonds 465.0

Heavy Atoms 1057.0

Ring Count 33.0

Amide Bonds 146.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0035814 VERIFIED: NO

Provenance & Taxonomy

OrganismCerthia familiaris [Animal]

FamilyBPI

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin

TargetGram-negative bacteria