Peptide Database

Peptide NameNT pro-BNP (N-terminal Pro-Brain natriuretic Peptide)

Function Ontology

Cardiovascular ▸ Vascular tone modulation ▸ Vasodilatory activity

Standard StatusStandard

Sequence Length76 amino acids

Chemical FormulaC364H596N114O116S

DescriptionStandard

        HPLGSPGSASDLETSGLQEQRNHLQGKLSELQVEQTSLEPLQESPRTPGVWKSREVATEGIRGHRKMVLYTLRAPR
    

Molecular Weight8457.39 Da

Isoelectric Point (pI)8.45

Net Charge (pH 7.0)1.04

Net Charge (pH 7.4) 0.67

Charge Density (pH 7.0) 0.0137

GRAVY Index-0.88

Hydrophobic Moment 0.62

Boman Index-0.18

Instability Index63.44

Aliphatic Index 75.66

Aromaticity 0.0263

Extinction Coeff. Reduced 6990.00

Extinction Coeff. Oxidized 6990.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 3726.82

LogP -44.34

H-bond Donors 129.0

H-bond Acceptors 121.0

Rotatable Bonds 283.0

Heavy Atoms 595.0

Ring Count 12.0

Amide Bonds 82.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0222555 VERIFIED: YES

Provenance & Taxonomy

Organismnot reported [other]

FamilyNatriuretic peptide

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermNone

Bio-Activity Profile

Function

Natriuretic Vasodilator

Half-LifeHuman plasma, in vitro; 5400 s

RECORD: Rec_0272832 VERIFIED: YES