Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length433 amino acids

Chemical FormulaC2199H3413N549O636S14

DescriptionStandard

        MQPKNAPILWGCFLLWNLYASSSQTDYPGIKARITQRALDYGVEVGVKTMEQMIKDMVIPDLKGSESLDFLKIDYVKYNFSNIKINAFSLPNASLTFVPGVGIRALSNHGTANISTNWDVKAPFLCPIVTNEVEALNLNISALEVLTKIDNYTVLDCSLINPPEITENYLDLNLKGSFYPLESLVDPPFPPVPFELPDRRDSMLYIGISEYFFKSASFAHFVAGALGVMLSTKEISNHFNQNAQGIGSLFSRIAEIYVLSQPFMLQIMATGPPEISLHPNNFSLDLPASIIMLTELENSTIEPIVSMDFVASTSVGLAILGQKLICSLSLNRFRLLLPETSHRDVTVVRFENILSSILHFGVFPLANTKLQQGFPLPNPYNISFVNSDIEVFEGFLLVSTDLKHEATSKQQSNLHNWGSLELVNGPWREQPVP
    

Molecular Weight48165.83 Da

Isoelectric Point (pI)5.02

Net Charge (pH 7.0)-13.78

Net Charge (pH 7.4) -14.56

Charge Density (pH 7.0) -0.0318

GRAVY Index0.11

Hydrophobic Moment 0.68

Boman Index0.17

Instability Index38.51

Aliphatic Index 103.09

Aromaticity 0.0993

Extinction Coeff. Reduced 45380.00

Extinction Coeff. Oxidized 45630.00

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Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0175128 VERIFIED: NO

Provenance & Taxonomy

OrganismNannospalax galili [Animal]

FamilyBPI

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin

TargetGram-negative bacteria

MethodQualitative functional evidence