Peptide Database

Peptide NameUnnamed

Function Ontology

Anticancer

Antimicrobial

Antimicrobial ▸ Antibacterial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive

Antimicrobial ▸ Antifungal

Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic

Toxicity / Safety ▸ Cytolysis / cell lysis ▸ Cytolytic activity

Standard StatusStandard

Sequence Length24 amino acids

Chemical FormulaC121H209N27O28S2

DescriptionStandard

        FLPVLAGLTPSIVPKLVCLLTKKC
    

Molecular Weight2554.25 Da

Isoelectric Point (pI)9.39

Net Charge (pH 7.0)2.74

Net Charge (pH 7.4) 2.50

Charge Density (pH 7.0) 0.1141

GRAVY Index1.27

Hydrophobic Moment 0.52

Boman Index0.39

Instability Index42.63

Aliphatic Index 154.17

Aromaticity 0.0417

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 125.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 845.00

LogP -2.75

H-bond Donors 30.0

H-bond Acceptors 33.0

Rotatable Bonds 80.0

Heavy Atoms 178.0

Ring Count 4.0

Amide Bonds 23.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0323860 VERIFIED: YES

Provenance & Taxonomy

OrganismRana pretiosa [Animal]

FamilyBrevinin

Structure & Mods

ConfigLinear peptide with a single intramolecular disulfide-stabilized loop [Linear]

ChiralityGene-encoded natural peptide composed of standard L-amino acids [L]

Disulfide18-24

Bio-Activity Profile

Function

Antimicrobial Antibacterial Anti-Gram-positive

TargetStaphylococcus aureus

Activity25.0 μM

MethodMIC

PaperJ.M. Conlon et al. / Developmental and Comparative Immunology 35 (2011) 644-649. Host defense peptides in skin secretions of the Oregon spotted frog Rana pretiosa: implications for species resistance to chytridiomycosis PMID21295070 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21295070/

RECORD: Rec_0326320 VERIFIED: YES

Provenance & Taxonomy

OrganismRana pretiosa [Animal]

FamilyBrevinin

Structure & Mods

ConfigLinear peptide with a single intramolecular disulfide-stabilized loop [Linear]

ChiralityGene-encoded natural peptide composed of standard L-amino acids [L]

Disulfide18-24

Bio-Activity Profile

Function

Antimicrobial Antifungal

PaperJ.M. Conlon et al. / Developmental and Comparative Immunology 35 (2011) 644-649. Host defense peptides in skin secretions of the Oregon spotted frog Rana pretiosa: implications for species resistance to chytridiomycosis PMID21295070 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21295070/

RECORD: Rec_0366045 VERIFIED: YES

Provenance & Taxonomy

OrganismRana pretiosa [Animal]

FamilyBrevinin

Structure & Mods

ConfigSingle-chain peptide backbone represented as a linear sequence entry [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Hemolytic

Targethuman erythrocytes

Activity80 μM

MethodLC50

RECORD: Rec_0417018 VERIFIED: YES

Provenance & Taxonomy

OrganismRana pretiosa [Animal]

FamilyBrevinin

Structure & Mods

ConfigLinear peptide with a single intramolecular disulfide-stabilized loop [Linear]

ChiralityGene-encoded natural peptide composed of standard L-amino acids [L]

Disulfide18-24

Bio-Activity Profile

Function

Hemolytic Cytolytic

TargetErythrocytes

Activity80.0 μM

MethodHC50

PaperJ.M. Conlon et al. / Developmental and Comparative Immunology 35 (2011) 644-649. Host defense peptides in skin secretions of the Oregon spotted frog Rana pretiosa: implications for species resistance to chytridiomycosis PMID21295070 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21295070/

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