Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length479 amino acids

Chemical FormulaC2348H3684N586O700S26

DescriptionStandard

        MRPSVIAVFTLLSCVCGENPGVKVVLTNKWLQYVKHVGAGWVQDKLEKITFPDISGDVNIHIGTVYYTLSGTTVTKCDLPEPVVEFSQDNTGVKTSIEGLSVALAGDWRTNFGLIHDGGTFEMAIFSMSLTSVVQLGKDSDGHLSVSSLSCDAQVGDVDIQFHGGASWIFQPFVDHFKGHIVDMIQSQICPKVQEFIVSVESDLQAMSVSVNVSEVLSFEIPLTDPPVIEASNLKMGLKGEFYSIKTHMEPPFVAQPFTMPEQPDHMLSVGMSEFTMNSASYGYFSAGQLQALINDSMIPPASPVRLNTSSMGVFIPQLPKQFPNLLMVLQVYASDSPMVSLQPGLGELGLQVGVIAYAIEPNTTQVPLFKLSSISKFSGKMWIADQKLKGSVTMDNFTLTLVSSEVGTFKTDALENGVKMGIKMMVLPKLNTLLGNGIPLPQMKQGHLVNSVLNIEKGFLDIYSDVEIEPAERNNNFL
    

Molecular Weight52155.56 Da

Isoelectric Point (pI)4.91

Net Charge (pH 7.0)-17.62

Net Charge (pH 7.4) -18.52

Charge Density (pH 7.0) -0.0368

GRAVY Index0.14

Hydrophobic Moment 0.61

Boman Index0.19

Instability Index44.42

Aliphatic Index 94.91

Aromaticity 0.0814

Extinction Coeff. Reduced 40910.00

Extinction Coeff. Oxidized 41160.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0399143 VERIFIED: NO

Provenance & Taxonomy

OrganismAustrofundulus limnaeus [Bacterium]

FamilyBPI

Tax ID52670

Structure & Mods

Configlinear polypeptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin Non-hemolytic

TargetGram-negative bacteria

MethodQualitative functional evidence