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MYP_048248
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Basic Information
Unnamed
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Mycobacterium
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
not Standard
20 amino acids
-
contains X representing unresolved or non-standard residue
Sequence
GFXGXXXGXFXGXGXXXXXX
Physicochemical Analysis
0.00 Da
0.00
0.00
0.00
0.00
0.00
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Residue Composition
Amino Acid Composition
Chemical Descriptors
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0080468 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
unspecified non-canonical residue at 3,5,6,7,9,11,13,15,16,17,18,19,20
Bio-Activity Profile
Antimicrobial Antibacterial
Enterococcus faecalis ATCC 29212
11.37 μM
MIC
PMID27387357 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/27387357/
RECORD: Rec_0080579 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Acetylation
Amidation
X(3/5/7/9/11/13/16)=A6c (1-aminocyclohexane carboxylic acid); X(6/15/17/18/19/20)=Dab (Diaminobutyric acid)
Bio-Activity Profile
Antimicrobial Anticancer
RL
1.7 μM
IC50
PaperAntibacterial and anticancer activity of a series of novel peptides incorporating cyclic tetra-substituted C(alpha) amino acids. Bioorg Med Chem. 2016 Sep 15;24(18):4056-4065. doi: 10.1016/j.bmc.2016.06.048. PMID: 27387357. PMID27387357 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/27387357/
RECORD: Rec_0082119 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
unspecified non-canonical residue at 3,5,6,7,9,11,13,15,16,17,18,19,20
Bio-Activity Profile
Antimicrobial Antibacterial
Pseudomonas aeruginosa ATCC 27853
1.48 μM
MIC
PMID27387357 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/27387357/
RECORD: Rec_0084739 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
unspecified non-canonical residue at 3,5,6,7,9,11,13,15,16,17,18,19,20
Bio-Activity Profile
Antimicrobial Antibacterial
Mycobacterium tuberculosis SRI 1377
11.37 μM
MIC
PMID27387357 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/27387357/
RECORD: Rec_0086431 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
unspecified non-canonical residue at 3,5,6,7,9,11,13,15,16,17,18,19,20
Bio-Activity Profile
Antimicrobial Antibacterial
Yersinia pestis NR641
47 μM
MIC
PMID27387357 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/27387357/
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