Peptide Database

Peptide NameSLAY-screened peptide P4292

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length14 amino acids

Chemical FormulaC78H105N21O21S2

DescriptionStandard

        AHFCIDCTFHHDYK
    

Molecular Weight1736.93 Da

Isoelectric Point (pI)6.26

Net Charge (pH 7.0)-0.96

Net Charge (pH 7.4) -1.34

Charge Density (pH 7.0) -0.0687

GRAVY Index-0.40

Hydrophobic Moment 0.30

Boman Index0.05

Instability Index27.91

Aliphatic Index 35.00

Aromaticity 0.2143

Extinction Coeff. Reduced 1490.00

Extinction Coeff. Oxidized 1615.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 668.74

LogP -4.58

H-bond Donors 25.0

H-bond Acceptors 25.0

Rotatable Bonds 52.0

Heavy Atoms 122.0

Ring Count 6.0

Amide Bonds 13.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0373876 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/