Peptide Database

Peptide Namer/hCRF(Human/rat corticotropin-releasing factor)

Function Ontology

ACTH release stimulation Neurotransmitter

Standard StatusStandard

Sequence Length41 amino acids

Chemical FormulaC206H342N58O62S

DescriptionStandard

        SQEPPISLVLTFHLLREVLEMTKADQLAQQAHSNRKLLDIA
    

Molecular Weight4655.34 Da

Isoelectric Point (pI)5.99

Net Charge (pH 7.0)-1.36

Net Charge (pH 7.4) -1.67

Charge Density (pH 7.0) -0.0331

GRAVY Index-0.13

Hydrophobic Moment 0.65

Boman Index0.01

Instability Index34.04

Aliphatic Index 119.02

Aromaticity 0.0244

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 0.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1946.04

LogP -17.41

H-bond Donors 65.0

H-bond Acceptors 64.0

Rotatable Bonds 158.0

Heavy Atoms 327.0

Ring Count 5.0

Amide Bonds 45.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0292509 VERIFIED: YES

Provenance & Taxonomy

OrganismHomo sapiens [Animal]; Rattus norvegicus [Animal]

FamilyGHRH/CRF

Tax ID9606;10116

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermNone

Bio-Activity Profile

Function

ACTH release stimulation

MethodRadioimmunoassay

Half-LifeRhesus monkey plasma, in vivo; 90 s

RECORD: Rec_0314268 VERIFIED: YES

Provenance & Taxonomy

OrganismOvis aries [Animal]

Tax ID9940