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MYP_048196
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Basic Information
Interferon beta-1a
Anticancer
Antimicrobial
Antimicrobial ▸ Antibacterial
Antiviral
Antiviral ▸ Anti-Coronavirus ▸ Anti-SARS-CoV-2
Immunology ▸ Immune modulation ▸ Cytokine modulation
Immunology ▸ Immune modulation ▸ Immunomodulatory activity
Immunology ▸ Immunomodulation ▸ Immunosuppressive
Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Host defense activity
Membrane / Ion-channel modulation ▸ Sodium channel modulation ▸ Sodium channel inhibitor
Regulatory peptide ▸ Cell signaling / Growth factor signaling ▸ Growth factor activity
Therapeutic / Biomedical activity ▸ Enzyme replacement therapy
Standard
166 amino acids
C908H1408N246O252S7
Standard
Sequence
MSYNLLGFLQRSSNFQCQKLLWQLNGRLEYCLKDRMNFDIPEEIKQLQQFQKEDAALTIYEMLQNIFAIFRQDSSSTGWNETIVENLLANVYHQINHLKTVLEEKLEKEDFTRGKLMSSLHLKRYYGRILHYLKAKEYSHCAWTIVRVEILRNFYFINRLTGYLRN
Physicochemical Analysis
20026.84 Da
8.93
3.93
3.36
0.0237
-0.43
0.71
-0.06
49.23
94.58
0.1325
31400.00
31525.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
8202.37
-73.98
288.0
268.0
684.0
1413.0
31.0
188.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0009818 VERIFIED: NO
Provenance & Taxonomy
Homo sapiens [Animal]; Chinese hamster ovary cell line [Animal]
Interferon
9606; 10029
Structure & Mods
single-chain therapeutic peptide/protein [Linear]
canonical L-amino-acid peptide [L]
Glycosylation, Phosphorylation
Bio-Activity Profile
Antimicrobial Antiviral Anticancer Immunomodulatory Enzyme replacement
10 hours
Evidence URLhttps://patents.google.com/patent/CA1341604/en PatentCA1341604
RECORD: Rec_0071100 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]; Cricetulus griseus [Animal]
Interferon
9606;10029
Structure & Mods
linear multidomain protein biologic [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Immunomodulatory Immunosuppressive Antiviral
10 h
PaperPubMed-linked source references: PMID:27835061; PMID:27314959; PMID:27126827; PMID:27035896; PMID:26384035; PMID:26039748; PMID:25941954; PMID:25846320; PMID:25666445 PMID27835061;27314959;27126827;27035896;26384035;26039748;25941954;25846320;25666445 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/27835061/
RECORD: Rec_0073177 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
alpha/beta interferon family
9606; 0
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
31-141
3-Tyr: Phosphotyrosine
Bio-Activity Profile
Cytokine Growth factor alpha beta interferon family Antibacterial Antiviral Host defense
PaperPDB 1AU1 structural record; X-ray; 2.20 A; chain A/B; residues 1-166
RECORD: Rec_0128050 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]; Cricetulus griseus [Animal]
Interferon
9606;10029
Structure & Mods
linear multidomain protein biologic [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Anticancer Antiviral Immunomodulatory
10 h
PaperPubMed-linked source references: PMID:27835061; PMID:27314959; PMID:27126827; PMID:27035896; PMID:26384035; PMID:26039748; PMID:25941954; PMID:25846320; PMID:25666445 PMID27835061;27314959;27126827;27035896;26384035;26039748;25941954;25846320;25666445 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/27835061/ PatentCA1341604
RECORD: Rec_0226652 VERIFIED: NO
Provenance & Taxonomy
Homo sapiens [Animal]; Cricetulus griseus [Animal]
Interferon
9606;10029
Structure & Mods
linear peptide/protein therapeutic [Linear]
canonical L-amino-acid peptide [L]
Glycosylation
Bio-Activity Profile
-
Approximately 78 hours
Evidence URLhttps://webs.iiitd.edu.in/raghava/thpdb2/display_thppid.php?details=Th1203
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