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MYP_048186
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Basic Information
Peptide 5
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antiviral
Antiviral ▸ Anti-Coronavirus ▸ Anti-SARS-CoV-2
Antiviral ▸ Anti-Herpesvirus ▸ Anti-HCMV
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition
Membrane / Ion-channel modulation ▸ Sodium channel modulation ▸ Sodium channel inhibitor
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
5 amino acids
C23H42N6O7
Standard
Sequence
GVLVQ
Physicochemical Analysis
514.62 Da
5.53
-0.24
-0.44
-0.0480
1.66
0.23
0.57
8.00
194.00
0.0000
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
222.81
-1.41
7.0
7.0
16.0
36.0
0.0
5.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0183209 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Defensin
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Ac
Bio-Activity Profile
Antiviral
SARS-CoV-19 UC-1074
20 μM
EC50
PMID34502335 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/34502335/
RECORD: Rec_0214115 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Acylation
Amidation
Bio-Activity Profile
Antimicrobial Anti-SARS-CoV-2 Cytotoxic
PMID34502335 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/34502335/
RECORD: Rec_0252958 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Synthetic peptide
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Acylation
Methyl amidation
Acylation; Methyl amidation
Bio-Activity Profile
Antiviral Anti-SARS-CoV-2 Entry inhibition
SARS-CoV-2 UC-1074 | Vero cells
20 μM
EC50
Mammalian: 30 h; Yeast: >20 h; E. coli: >10 h
PaperPeptide Derivatives of the Zonulin Inhibitor Larazotide (AT1001) as Potential Anti SARS-CoV-2: Molecular Modelling, Synthesis and Bioactivity Evaluation. | Di Micco S, Musella S, Sala M, Scala MC, Andrei G, Snoeck R, Bifulco G, Campiglia P, Fasano A. | Int J Mol Sci. 2021 Aug 30;22(17):9427. | DOI:10.3390/ijms22179427 | PMID:34502335 PMID34502335 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/34502335/
RECORD: Rec_0258753 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Acylation
Amidation
Bio-Activity Profile
Antimicrobial Anti-SARS-CoV-2
cytomegalovirus (HCMV) Davis strain:inhibition of virus activity in human embryonic lung (HEL) cells
100 μM
EC50
PMID34502335 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/34502335/
RECORD: Rec_0277703 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Acylation
Amidation
Bio-Activity Profile
Antimicrobial Anti-SARS-CoV-2
varicella-zoster virus (VZV) TK-VZV Strain 07-1:inhibition of virus activity in human embryonic lung (HEL) cells
100 μM
EC50
PMID34502335 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/34502335/
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