Peptide Database

Peptide NameCathepsin G (EC 3.4.21.20)

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive

Antimicrobial ▸ Antibacterial ▸ Anti-Mycobacterium

Antimicrobial ▸ Anti-biofilm ▸ Biofilm inhibition

Antimicrobial ▸ Antibiotic activity

Enzyme / Catalytic activity ▸ Hydrolase

Enzyme / Catalytic activity ▸ Protease

Enzyme / Catalytic activity ▸ Protease ▸ Serine protease

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length250 amino acids

Chemical FormulaC1227H1968N372O345S11

DescriptionStandard

        MQPLLFLLIFVLFQEDEAGKIIGGREARPNSHPYMAFLLIQSPEGLSACGGFLVREDFVLTAGHCFGSSINVTLGAHNIRRQEGTQQHITVLRAIRHPDYNPPPVIQNDIMLLQLRSRARRSRAVKPVALPQATKRVQPGALCTVAGWGLVSQRRGTNVLQEVKLRVQTDQTCANRFQFYNSQTQICVGNPRERKSAFKGDSGGPLVCNNVAQGIVSYGSSSGNPPAVFTRIQSFMPWIKRTMRRLSSRY
    

Molecular Weight27803.75 Da

Isoelectric Point (pI)10.55

Net Charge (pH 7.0)16.89

Net Charge (pH 7.4) 16.30

Charge Density (pH 7.0) 0.0676

GRAVY Index-0.24

Hydrophobic Moment 0.80

Boman Index-0.02

Instability Index61.32

Aliphatic Index 85.00

Aromaticity 0.0760

Extinction Coeff. Reduced 18450.00

Extinction Coeff. Oxidized 18825.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0023849 VERIFIED: YES

Provenance & Taxonomy

OrganismRattus norvegicus [Animal]

FamilyPeptidase S1

Tax ID10116

Structure & Mods

Configlinear peptide [Linear]

Chiralitynoncanonical stereochemical modification [Modified]

Bio-Activity Profile

Function

Antimicrobial Antibiotic Antibiofilm Anti-tuberculosis Anti-Gram-negative Anti-Gram-positive Hydrolase Protease Serine protease Cytotoxic Proteolytic Non-hemolytic

TargetM. tuberculosis (Gram-positive)

RECORD: Rec_0114638 VERIFIED: YES

Provenance & Taxonomy

OrganismRattus norvegicus [Animal]

FamilyPeptidase S1

Tax ID10116

Structure & Mods

Configlinear peptide [Linear]

Chiralitynoncanonical stereochemical modification [Modified]

Bio-Activity Profile

Function

Antimicrobial Antibiotic Antibiofilm Anti-tuberculosis Anti-Gram-negative Anti-Gram-positive Hydrolase Protease Serine protease Cytotoxic Proteolytic Non-hemolytic

TargetN. gonorrhoeae (Gram-negative)

RECORD: Rec_0243371 VERIFIED: YES

Provenance & Taxonomy

OrganismRattus norvegicus [Animal]

FamilyPeptidase S1

Tax ID10116

Structure & Mods

Configlinear peptide [Linear]

Chiralitynoncanonical stereochemical modification [Modified]

Bio-Activity Profile

Function

Antimicrobial Antibiotic Antibiofilm Anti-tuberculosis Anti-Gram-negative Anti-Gram-positive Hydrolase Protease Serine protease Cytotoxic Proteolytic Non-hemolytic

TargetStaphylococcus aureus (Gram-positive)