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MYP_048168
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Basic Information
Brevinin-1DYa
Anticancer
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytolysis / cell lysis ▸ Cytolytic activity
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
20 amino acids
C109H177N23O22S2
Standard
Sequence
FLSLALAALPKFLCLVFKKC
Physicochemical Analysis
2225.84 Da
9.39
2.74
2.50
0.1369
1.58
0.53
0.44
21.25
146.50
0.1500
0.00
125.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
705.72
0.07
26.0
27.0
72.0
156.0
4.0
19.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0045436 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Brevinin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial
Human erythrocytes
5 μM
LC50
Paperhttps://pubmed.ncbi.nlm.nih.gov/17688900/ PMID17688900 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/17688900/
RECORD: Rec_0052883 VERIFIED: YES
Provenance & Taxonomy
Rana huanrensis [Animal]
Brevinin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
RECORD: Rec_0114196 VERIFIED: YES
Provenance & Taxonomy
Rana dybowskii [Animal]
Brevinin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Hemolytic Anti-Gram-positive Anti-Gram-negative
Staphylococcus aureus, Escherichia coli
15 μM
MIC
RECORD: Rec_0133760 VERIFIED: YES
Provenance & Taxonomy
Rana dybowskii [Animal]
Brevinin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
14-20
Bio-Activity Profile
Antimicrobial Antifungal Anticancer
Inactive: Escherichia coli
>512 μM
MIC
PaperCytolytic peptides belonging to the brevinin-1 and brevinin-2 families isolated from the skin of the Japanese brown frog, Rana dybowskii
RECORD: Rec_0153328 VERIFIED: YES
Provenance & Taxonomy
Rana amurensis [Animal]
Brevinin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative
Staphylococcus aureus
32 μM
MIC
PMID29366784 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29366784/
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