Peptide Database

Peptide NameAlteplase

Function Ontology

Hemostasis ▸ Anticoagulant activity

Hemostasis ▸ Fibrinolytic activity

Therapeutic / Biomedical activity ▸ Enzyme replacement therapy

Standard StatusStandard

Sequence Length527 amino acids

Chemical FormulaC2569H3928N746O781S40

DescriptionStandard

        SYQVICRDEKTQMIYQQHQSWLRPVLRSNRVEYCWCNSGRAQCHSVPVKSCSEPRCFNGGTCQQALYFSDFVCQCPEGFAGKCCEIDTRATCYEDQGISYRGTWSTAESGAECTNWNSSALAQKPYSGRRPDAIRLGLGNHNYCRNPDRDSKPWCYVFKAGKYSSEFCSTPACSEGNSDCYFGNGSAYRGTHSLTESGASCLPWNSMILIGKVYTAQNPSAQALGLGKHNYCRNPDGDAKPWCHVLKNRRLTWEYCDVPSCSTCGLRQYSQPQFRIKGGLFADIASHPWQAAIFAKHRRSPGERFLCGGILISSCWILSAAHCFQERFPPHHLTVILGRTYRVVPGEEEQKFEVEKYIVHKEFDDDTYDNDIALLQLKSDSSRCAQESSVVRTVCLPPADLQLPDWTECELSGYGKHEALSPFYSERLKEAHVRLYPSSRCTSQHLLNRTVTDNMLCAGDTRSGGPQANLHDACQGDSGGPLVCLNDGRMTLVGIISWGLGCGQKDVPGVYTKVTNYLDWIRDNMRP
    

Molecular Weight59041.80 Da

Isoelectric Point (pI)7.61

Net Charge (pH 7.0)2.57

Net Charge (pH 7.4) 0.91

Charge Density (pH 7.0) 0.0049

GRAVY Index-0.52

Hydrophobic Moment 0.74

Boman Index-0.06

Instability Index45.37

Aliphatic Index 62.75

Aromaticity 0.1006

Extinction Coeff. Reduced 107260.00

Extinction Coeff. Oxidized 109385.00

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Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0252337 VERIFIED: NO

Provenance & Taxonomy

OrganismHomo sapiens [Animal]; Chinese hamster ovary cell line [Animal]

FamilyEnzyme

Tax ID9606; 10029

Structure & Mods

Configsingle-chain therapeutic peptide/protein [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Other ModsGlycosylation, Phosphorylation

Bio-Activity Profile

Function

Enzyme replacement Anticoagulant Thrombolytic Fibrinolytic

TargetCHO

RECORD: Rec_0274511 VERIFIED: NO