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MYP_048116
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Basic Information
Brevinin-1DY1
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antifungal
Membrane / Ion-channel modulation ▸ Calcium channel modulation ▸ Calcium channel inhibitor
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Standard
24 amino acids
C122H204N30O27S2
Standard
Sequence
FLPLLAGLAANFLPTIICKIARKC
Physicochemical Analysis
2587.24 Da
9.50
2.74
2.50
0.1141
1.26
0.69
0.39
15.83
146.67
0.0833
0.00
125.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
892.30
-3.24
32.0
32.0
82.0
181.0
4.0
24.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0063085 VERIFIED: YES
Provenance & Taxonomy
Amolops daiyunensis [Animal]
Brevinin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Hemolytic
human red blood cells
100 % hemolysis at 200 μM
Hemolysis
PMID28402481 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28402481/
RECORD: Rec_0075222 VERIFIED: YES
Provenance & Taxonomy
Amolops daiyunensis [Animal]
Brevinin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal
Pseudomonas aeruginosa CGMCC 1.50
PMID28402481 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28402481/
RECORD: Rec_0084472 VERIFIED: YES
Provenance & Taxonomy
Amolops daiyunensis [Animal]
Brevinin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
18-24
Bio-Activity Profile
Antimicrobial Antioxidant
Staphylococcus aureus ATCC 25923, Enterococcus faecalis 981, N. asteroides 201118
37.5 μM
MIC
PaperIdentification and functional analyses of novel antioxidant peptides and antimicrobial peptides from skin secretions of four East Asian frog species. PMID28402481 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28402481/
RECORD: Rec_0091448 VERIFIED: YES
Provenance & Taxonomy
Amolops daiyunensis [Animal]
Brevinin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal
Escherichia coli ATCC 25922
37.5 μM
MIC
PMID28402481 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28402481/
RECORD: Rec_0133898 VERIFIED: YES
Provenance & Taxonomy
Amolops wuyiensis [Animal]
Brevinin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
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