Peptide Database

Peptide NameBactericidal permeability-increasing protein

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length507 amino acids

Chemical FormulaC2581H3993N639O743S17

DescriptionStandard

        MYAKTIPVIWGCFFLWNLYSSSSQTIYPGIKARVTQRALDYGVQAGMEMIGQMLKERNIPDLQGSESLDFLKVDYVDYNFSNIKINAFSFPNTSLAFVPGVGIKALTNHGTANVSTNWAVKSPLFKDAGGANLFLSGVYFTGNIILNRNDFGQPLLKLEDCYAQVSHAHVSFFGQFSVLYNSFAEPMEKPILKNLNEMLCPIITGEVEALNVNLSTLEVLTKIDNYTLLDYSIIDSPEITENSLDVNFKGTFYPLENLVDPPFSPAPFVLPERSDSMLYIGISEYFFKSASFAYYTAGAFDVTFSTKEISNHLIQNSQGLGNVLSRIADIYILAQPFMVRIMATEPPIINLQPGNFSLDIPASIMMLTQPENSTMKTIVSMDFVASTSVGLVILGQRLICSLSLNRFRLSLPEPKRSKIEVLRFENILSSILHFGVLPLANAKLQQGFPLPNPYNISFVNSDIEVLQSFLLISTDLRYEASLKQQPSLAGWKDLNLLSGQWQGKPAP
    

Molecular Weight56407.25 Da

Isoelectric Point (pI)5.21

Net Charge (pH 7.0)-9.06

Net Charge (pH 7.4) -9.70

Charge Density (pH 7.0) -0.0179

GRAVY Index0.11

Hydrophobic Moment 0.68

Boman Index0.17

Instability Index39.15

Aliphatic Index 100.00

Aromaticity 0.1124

Extinction Coeff. Reduced 55810.00

Extinction Coeff. Oxidized 56060.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0058745 VERIFIED: NO

Provenance & Taxonomy

OrganismOryctolagus cuniculus [Animal]

FamilyBPI/LBP

Tax ID9986

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxic Non-hemolytic Non-ribosomal

TargetGram-negative bacteria

MethodQualitative functional evidence