Peptide Database

Peptide NameBeta-defensin 11

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Standard StatusStandard

Sequence Length69 amino acids

Chemical FormulaC354H551N109O91S9

DescriptionStandard

        MRTLCSLLLIGCLLFSYDTPVVGFLRRSVSGFQECHSKGGYCYRYYCPRPHRRLGSCYPYAANCCRRRR
    

Molecular Weight8078.42 Da

Isoelectric Point (pI)9.64

Net Charge (pH 7.0)9.59

Net Charge (pH 7.4) 9.14

Charge Density (pH 7.0) 0.1390

GRAVY Index-0.24

Hydrophobic Moment 0.64

Boman Index-0.12

Instability Index90.51

Aliphatic Index 66.38

Aromaticity 0.1449

Extinction Coeff. Reduced 10430.00

Extinction Coeff. Oxidized 10930.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 3235.47

LogP -31.69

H-bond Donors 129.0

H-bond Acceptors 112.0

Rotatable Bonds 255.0

Heavy Atoms 563.0

Ring Count 16.0

Amide Bonds 70.0

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.

2D CHEMICAL STRUCTURE

Drag to move

Drag to move. Use the buttons to zoom.

RECORD: Rec_0381291 VERIFIED: NO

Provenance & Taxonomy

OrganismRattus norvegicus [Animal]

FamilyDefensin

Tax ID10116

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Defensin Non-hemolytic Non-ribosomal

MethodQualitative functional evidence

PaperCross-species analysis of the mammalian beta-defensin gene family: presence of syntenic gene clusters and preferential expression in the male reproductive tract PMID16033865 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16033865/; https://www.uniprot.org/uniprotkb/Q32ZI0/entry; https://bblserver.org.in/ampdb/