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MYP_048038
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Basic Information
NP-1
Anticancer
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Antiviral
Antiviral ▸ Anti-Herpesvirus ▸ Anti-HSV
Antiviral ▸ Antiviral mechanism ▸ Viral fusion inhibition
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Standard
32 amino acids
C158H261N59O41S6
Standard
Sequence
VTCYCRRTRCGFRERLSGACGYRGRIYRLCCR
Physicochemical Analysis
3835.52 Da
9.99
7.67
7.37
0.2398
-0.49
0.63
-0.41
20.14
48.75
0.1250
4470.00
4845.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1681.20
-19.58
73.0
55.0
126.0
264.0
4.0
31.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0248494 VERIFIED: NO
Provenance & Taxonomy
not reported [other]
Structure & Mods
topology not specified [Not included yet]
stereochemistry not specified [Other]
Bio-Activity Profile
Anticancer
RECORD: Rec_0272102 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Defensin
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Salmonella typhimurium 7731
128 μM
MIC
PMID29282543 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29282543/
RECORD: Rec_0280116 VERIFIED: NO
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide; DSSP H 0.0%, E 59.4%, T 18.8%, C 21.9% [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antibacterial Antiviral Antimicrobial Antifungal Anti-Gram-positive Anti-Gram-negative
PaperCAMP: Collection of sequences and structures of antimicrobial peptides PMID24265220 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24265220/
RECORD: Rec_0283077 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Defensin
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
S. faecalis ATCC 29212
128 μM
MIC
PMID29282543 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29282543/
RECORD: Rec_0289925 VERIFIED: YES
Provenance & Taxonomy
Rattus norvegicus [Animal]
Defensin
10116
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
3-31, 5-20, 10-30
Disulfide bonds between Cys3 and Cys31,Cys5 and Cys20,Cys10 and Cys30.
Bio-Activity Profile
Antiviral Anti-HSV Fusion inhibition
HSV-2 | Vero cells
25 μg/mL
% inhibition
Mammalian: 100 h; Yeast: >20 h; E. coli: >10 h
PaperNP-1, a rabbit alpha-defensin, prevents the entry and intercellular spread of herpes simplex virus type 2. | Sinha S, Cheshenko N, Lehrer RI, Herold BC. | Antimicrob Agents Chemother. 2003 Feb;47(2):494-500. | DOI:10.1128/AAC.47.2.494-500.2003 | PMID:12543649 PMID12543649 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/12543649/
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