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MYP_048038
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Basic Information
NP-1
Anticancer
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Antiviral
Antiviral ▸ Anti-Herpesvirus ▸ Anti-HSV
Antiviral ▸ Antiviral mechanism ▸ Viral fusion inhibition
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Standard
32 amino acids
C158H261N59O41S6
Standard
Sequence
VTCYCRRTRCGFRERLSGACGYRGRIYRLCCR
Physicochemical Analysis
3835.52 Da
9.99
7.67
7.37
0.2398
-0.49
0.63
-0.41
20.14
48.75
0.1250
4470.00
4845.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1681.20
-19.58
73.0
55.0
126.0
264.0
4.0
31.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0096125 VERIFIED: YES
Provenance & Taxonomy
Rattus norvegicus [Animal]
10116
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
3-31, 5-20, 10-30
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal
Staphylococcus aureus 502A [18 h]
100 CFU/mL
MIC
PMID2543629;7594610 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/2543629/
RECORD: Rec_0110221 VERIFIED: YES
Provenance & Taxonomy
Rattus norvegicus [Animal]
Defensin
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
Three disulfide bonds
Bio-Activity Profile
Antimicrobial Antifungal Antiviral
Escherichia coli ML-35, S. typhimurium LT2, Pseudomonas aeruginosa mucoid
PaperPurification and antimicrobial properties of three defensins from rat neutrophils
RECORD: Rec_0144793 VERIFIED: YES
Provenance & Taxonomy
Rattus norvegicus [Animal]
10116
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
3-31, 5-20, 10-30
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal
Cryptococcus neoformans A-383 [18 h]
170 CFU/mL
MIC
PMID2543629;7594610 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/2543629/
RECORD: Rec_0182879 VERIFIED: YES
Provenance & Taxonomy
Rattus norvegicus [Animal]
10116
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
3-31, 5-20, 10-30
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal
Candida albicans 820 [18 h]
100 CFU/mL
MIC
PMID2543629;7594610 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/2543629/
RECORD: Rec_0186433 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Defensin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial
PaperEisenhauer P. B., Harwig S. S., Szklarek D., Ganz T., Selsted M. E., Lehrer R. I.. Purification and antimicrobial properties of three defensins from rat neutrophils. Infect. Immun., 57, 2021-2027, 1989.
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