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MYP_048017
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Basic Information
11-P9
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antiviral
Antiviral ▸ Anti-Pneumovirus ▸ Anti-RSV
Antiviral ▸ Antiviral mechanism ▸ Viral replication inhibition
Antiviral ▸ Antiviral mechanism ▸ Viral replication inhibition ▸ Replication inhibitor
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
12 amino acids
C64H116N24O15S2
Standard
Sequence
HRILMRIRQMAT
Physicochemical Analysis
1525.89 Da
12.00
2.85
2.59
0.2373
-0.21
0.65
-0.26
45.27
105.83
0.0000
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
661.12
-5.20
25.0
21.0
53.0
105.0
1.0
12.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0051665 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Synthetic peptide
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Anti-RSV Replication inhibition
Porcine reproductive and respiratory syndrome virus (PRRSV) | MARC-145 cells
120.5 μM
IC50
Mammalian: 3.5 h; Yeast: 10 min; E. coli: >10 h
PaperAntiviral activity of phage display selected peptides against Porcine reproductive and respiratory syndrome virus in vitro. | Liu K, Feng X, Ma Z, Luo C, Zhou B, Cao R, Huang L, Miao D, Pang R, He D, Lian X, Chen P. | Virology. 2012 Oct 10;432(1):73-80. | DOI:10.1016/j.virol.2012.05.010 | PMID:22743126 PMID22743126 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22743126/
RECORD: Rec_0103386 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide; DSSP H 0.0%, E 0.0%, T 33.3%, C 66.7% [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Antimicrobial
PaperAVPdb: a database of experimentally validated antiviral peptides targeting medically important viruses PMID24285301 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24285301/
RECORD: Rec_0170822 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Hemolytic
MARC-145 cells (50% Cell death at >500 microM
145 μM
Hemolysis
PMID22743126 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22743126/
RECORD: Rec_0213766 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Library-derived peptide
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral Replication inhibitor
Porcine reproductive and respiratory syndrome virus (Replication); MARC-145
120.5239 μM
MTT assay
PaperAntiviral activity of phage display selected peptides against Porcine reproductive and respiratory syndrome virus in vitro. | Liu K, Feng X, Ma Z, Luo C, Zhou B, Cao R, Huang L, Miao D, Pang R, He D, Lian X, Chen P. | Virology. 2012 | PMID:22743126 PMID22743126 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22743126/
RECORD: Rec_0226783 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral
Porcine reproductive and respiratory syndrome virus(PRRSV):inhibition of PRRSV replication in MARC-145 cells
120.5239 μM
IC50
PaperPubMed PMID: 22743126 PMID22743126 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22743126/
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