Peptide Database

Peptide NameSLAY-screened peptide P5479

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length20 amino acids

Chemical FormulaC95H161N27O29S3

DescriptionStandard

        PMRIKCIGDSTALFEKNKSC
    

Molecular Weight2241.65 Da

Isoelectric Point (pI)8.96

Net Charge (pH 7.0)1.94

Net Charge (pH 7.4) 1.85

Charge Density (pH 7.0) 0.0970

GRAVY Index-0.34

Hydrophobic Moment 0.38

Boman Index-0.12

Instability Index35.48

Aliphatic Index 63.50

Aromaticity 0.0500

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 125.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 920.57

LogP -10.09

H-bond Donors 35.0

H-bond Acceptors 34.0

Rotatable Bonds 78.0

Heavy Atoms 154.0

Ring Count 2.0

Amide Bonds 20.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0304565 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/