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MYP_047915
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Basic Information
G149-165(derived from RSV attachment glycoprotein)
Antimicrobial
Antiviral
Antiviral ▸ Anti-Pneumovirus ▸ Anti-RSV
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition
Therapeutic / Biomedical activity ▸ Protective bioactivity ▸ Cell protection ▸ Cytoprotection
Standard
17 amino acids
C92H140N30O26
Standard
Sequence
KQRQNKPPSKPNNDFHF
Physicochemical Analysis
2082.28 Da
10.29
2.85
2.59
0.1674
-2.38
0.43
-0.58
51.83
0.00
0.1176
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
944.17
-11.60
29.0
30.0
67.0
148.0
6.0
21.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0011312 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
cyclic/stapled peptide [Cyclic]
canonical L-amino-acid peptide [L]
Acetylation
Amidation
Disulfide bond(s) reported
Bio-Activity Profile
Antimicrobial Antiviral
PaperPubMed PMID: 11487583 PMID11487583 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/11487583/
RECORD: Rec_0210517 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
cyclic/stapled peptide [Cyclic]
canonical L-amino-acid peptide [L]
Acetylation
Amidation
Disulfide bond(s) reported
Bio-Activity Profile
Antimicrobial Antiviral
Respiratory syncytial virus(RSV):inhibition of the cytopathic effect of RSV in HEp-2 cells
240 μM
IC50
PaperPubMed PMID: 11487583 PMID11487583 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/11487583/
RECORD: Rec_0225785 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide; DSSP H 0.0%, E 0.0%, T 35.3%, C 64.7% [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Antimicrobial
PaperAVPdb: a database of experimentally validated antiviral peptides targeting medically important viruses PMID24285301 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24285301/
RECORD: Rec_0329307 VERIFIED: YES
Provenance & Taxonomy
Human orthopneumovirus [Virus]
Virus-derived peptide
11250;0
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral Cytoprotective
Respiratory syncytial virus (Cytopathic effect); HEp-2
240 μM
NMR
PaperAntiviral activity and structural characteristics of the nonglycosylated central subdomain of human respiratory syncytial virus attachment (G) glycoprotein. | Gorman JJ, McKimm-Breschkin JL, Norton RS, Barnham KJ. | J Biol Chem. 2001 | PMID:11487583 PMID11487583 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/11487583/
RECORD: Rec_0394324 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Protein-derived synthetic peptide
32630
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
Acetylation
Amidation
The peptide formed two disulfide bonds.
Bio-Activity Profile
Antiviral Anti-RSV Entry inhibition
Respiratory syncytial virus(RSV) | HEp-2 cells
240 μM
IC50
Mammalian: 1.3 h; Yeast: 3 min; E. coli: 2 min
PaperAntiviral activity and structural characteristics of the nonglycosylated central subdomain of human respiratory syncytial virus attachment (G) glycoprotein. | Gorman JJ, McKimm-Breschkin JL, Norton RS, Barnham KJ. | J Biol Chem. 2001 Oct 19;276(42):38988-94. | DOI:10.1074/jbc.M106288200 | PMID:11487583 PMID11487583 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/11487583/