Peptide Database

Peptide NameAndexanet alfa

Function Ontology

Hemostasis ▸ Anticoagulant activity

Therapeutic / Biomedical activity ▸ Enzyme replacement therapy

Standard StatusStandard

Sequence Length365 amino acids

Chemical FormulaC1786H2799N509O545S27

DescriptionStandard

        ANSFLFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRRKRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDAGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK
    

Molecular Weight40987.17 Da

Isoelectric Point (pI)8.37

Net Charge (pH 7.0)6.25

Net Charge (pH 7.4) 5.26

Charge Density (pH 7.0) 0.0171

GRAVY Index-0.57

Hydrophobic Moment 0.76

Boman Index-0.10

Instability Index39.96

Aliphatic Index 61.18

Aromaticity 0.0932

Extinction Coeff. Reduced 45380.00

Extinction Coeff. Oxidized 46755.00

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Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0014626 VERIFIED: NO

Provenance & Taxonomy

OrganismHomo sapiens [Animal]; Rattus norvegicus [Animal]

FamilyCoagulation factor

Tax ID9606;10116

Structure & Mods

Configlinear peptide/protein therapeutic [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Other ModsPhosphorylation, Lipidation

Bio-Activity Profile

Function

Coagulation factor replacement Anticoagulant

Half-LifeThe elimination half-life ranges from 5 to 7 hours [L3725].

RECORD: Rec_0108076 VERIFIED: NO