Peptide Database

Peptide NameEsculentin-2ISa

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive ▸ Anti-Staphylococcus aureus

Antimicrobial ▸ Antibiotic activity

Antimicrobial ▸ Antifungal

Antimicrobial ▸ Antifungal ▸ Anti-Candida

Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Defense peptide

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Standard StatusStandard

Sequence Length78 amino acids

Chemical FormulaC384H642N98O113S5

DescriptionStandard

        MFTLKKSLLLLFFLGTISLSVCKQERDADYEDKGEVEEVKRGIFSLIKGAAKLITKTVAKEAGKTGLELMACKVTNQC
    

Molecular Weight8600.12 Da

Isoelectric Point (pI)8.84

Net Charge (pH 7.0)2.48

Net Charge (pH 7.4) 2.19

Charge Density (pH 7.0) 0.0318

GRAVY Index0.07

Hydrophobic Moment 0.68

Boman Index0.04

Instability Index10.93

Aliphatic Index 101.28

Aromaticity 0.0641

Extinction Coeff. Reduced 1490.00

Extinction Coeff. Oxidized 1615.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 3438.84

LogP -29.09

H-bond Donors 123.0

H-bond Acceptors 121.0

Rotatable Bonds 306.0

Heavy Atoms 600.0

Ring Count 5.0

Amide Bonds 80.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0000923 VERIFIED: YES

Provenance & Taxonomy

OrganismOdorrana ishikawae [Animal]

FamilyFrog skin active peptide (FSAP); Esculentin subfamily

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Defense peptide Antimicrobial Antibiotic Antifungal Anti-MRSA Anti-Candida Anti-Gram-negative Anti-Gram-positive Non-hemolytic

TargetStaphylococcus aureus (Gram-positive)

RECORD: Rec_0090230 VERIFIED: NO

Provenance & Taxonomy

OrganismOdorrana ishikawae [Animal]

FamilyEsculentin

Structure & Mods

ConfigSingle-chain peptide backbone represented as a linear sequence entry [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial

RECORD: Rec_0175111 VERIFIED: YES

Provenance & Taxonomy

OrganismOdorrana ishikawae [Animal]

FamilyFrog skin active peptide (FSAP); Esculentin subfamily

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Defense peptide Antimicrobial Antibiotic Antifungal Anti-MRSA Anti-Candida Anti-Gram-negative Anti-Gram-positive Non-hemolytic

TargetCandida albicans

RECORD: Rec_0191382 VERIFIED: YES

Provenance & Taxonomy

OrganismOdorrana ishikawae [Animal]

FamilyFrog skin active peptide (FSAP); Esculentin subfamily

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Defense peptide Antimicrobial Antibiotic Antifungal Anti-MRSA Anti-Candida Anti-Gram-negative Anti-Gram-positive Non-hemolytic

TargetEscherichia coli (Gram-negative)

RECORD: Rec_0241188 VERIFIED: YES

Provenance & Taxonomy

OrganismOdorrana ishikawae [Animal]

FamilyFrog skin active peptide (FSAP); Esculentin subfamily

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Defense peptide Antimicrobial Antibiotic Antifungal Anti-MRSA Anti-Candida Anti-Gram-negative Anti-Gram-positive Non-hemolytic

TargetBacillus subtilis (Gram-positive)