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MYP_047848
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Basic Information
Penilumamide D
Antimicrobial
Antimicrobial ▸ Antibacterial
Antiviral
Cardiovascular
Cardiovascular ▸ Blood pressure regulation ▸ Antihypertensive
Enzyme modulation ▸ Enzyme inhibition ▸ ACE inhibition ▸ ACE inhibitory
Other / Curated residual function label ▸ Generic enzyme inhibition annotation
not Standard
3 amino acids
-
contains X representing unresolved or non-standard residue
Sequence
XAX
Physicochemical Analysis
0.00 Da
0.00
0.00
0.00
0.00
0.00
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Residue Composition
Amino Acid Composition
Chemical Descriptors
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0092101 VERIFIED: YES
Provenance & Taxonomy
Bothrops jararaca [Animal]; synthetic construct [Synthetic]
ACE inhibitor
32630
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
Ethyl-pentanoyl
Non-standard residues/X at 1, 3
Bio-Activity Profile
Enzyme inhibitory ACE inhibitory Antihypertensive Cardiovascular
Human angiotensin-converting enzyme
Clinical/Human: Perindopril, 1.2 h; Peridoprilat, 30-120 h. The long half life of peridoprilat is due to its slow dissociation from ACE binding sites.
Evidence URLhttps://www.ema.europa.eu/en/medicines/human/referrals/coversyl-0
RECORD: Rec_0132465 VERIFIED: YES
Provenance & Taxonomy
Stagonospora trichophoricola,Aspergillus sp. [Fungus]
Structure & Mods
linear peptide [Linear]
mixed L/D amino-acid peptide [Mixed]
unspecified non-canonical residue at 1,3
Bio-Activity Profile
Antimicrobial Antibacterial Antiviral
Human lung carcinoma A549
PMID28676717 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28676717/
RECORD: Rec_0229802 VERIFIED: YES
Provenance & Taxonomy
Stagonospora trichophoricola,Aspergillus sp. [Fungus]
Structure & Mods
linear peptide [Linear]
mixed L/D amino-acid peptide [Mixed]
unspecified non-canonical residue at 1,3
Bio-Activity Profile
Antimicrobial Antibacterial Antiviral
Staphylococcus aureus ATCC 6538
100 μg/mL
MIC
PMID28676717 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28676717/
RECORD: Rec_0234815 VERIFIED: YES
Provenance & Taxonomy
Stagonospora trichophoricola,Aspergillus sp. [Fungus]
Structure & Mods
linear peptide [Linear]
mixed L/D amino-acid peptide [Mixed]
unspecified non-canonical residue at 1,3
Bio-Activity Profile
Antimicrobial Antibacterial Antiviral
Respiratory syncytial virus
PMID28676717 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28676717/
RECORD: Rec_0299006 VERIFIED: YES
Provenance & Taxonomy
Stagonospora trichophoricola,Aspergillus sp. [Fungus]
Structure & Mods
linear peptide [Linear]
mixed L/D amino-acid peptide [Mixed]
unspecified non-canonical residue at 1,3
Bio-Activity Profile
Antimicrobial Antibacterial Antiviral
Escherichia coli
PMID28676717 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28676717/
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