Peptide Database

Peptide NameLantibiotic nukacin (Nukacin KQ-1) (Nukacin KQU-131)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Standard StatusStandard

Sequence Length57 amino acids

Chemical FormulaC277H444N72O91S7

DescriptionStandard

        MENSKIMKDIEVANLLEEVQEDELNEVLGAKKKSGVIPTVSHDCHMNTFQFMFTCCS
    

Molecular Weight6463.37 Da

Isoelectric Point (pI)4.71

Net Charge (pH 7.0)-5.34

Net Charge (pH 7.4) -5.72

Charge Density (pH 7.0) -0.0936

GRAVY Index-0.22

Hydrophobic Moment 0.52

Boman Index0.02

Instability Index31.60

Aliphatic Index 76.84

Aromaticity 0.0526

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 125.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 2644.74

LogP -26.31

H-bond Donors 90.0

H-bond Acceptors 95.0

Rotatable Bonds 224.0

Heavy Atoms 447.0

Ring Count 6.0

Amide Bonds 62.0

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.

2D CHEMICAL STRUCTURE

Drag to move

Drag to move. Use the buttons to zoom.

RECORD: Rec_0248760 VERIFIED: YES

Provenance & Taxonomy

OrganismStaphylococcus hominis [Bacterium]

FamilyLantibiotic

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Bacteriocin Lantibiotic Anti-Gram-positive Non-hemolytic

TargetGram-positive bacteria