Peptide Database

Peptide NamePotassium channel toxin alpha-KTx 10.4

Function Ontology

Membrane / Ion-channel modulation ▸ Ion channel modulation

Venom / Toxin ▸ General toxin ▸ Toxin

Standard StatusStandard

Sequence Length33 amino acids

Chemical FormulaC159H255N51O46S6

DescriptionStandard

        AVCVYRTCDKDCKRRGYRSGKCINNACKCYPYA
    

Molecular Weight3809.43 Da

Isoelectric Point (pI)9.24

Net Charge (pH 7.0)5.73

Net Charge (pH 7.4) 5.44

Charge Density (pH 7.0) 0.1737

GRAVY Index-0.71

Hydrophobic Moment 0.74

Boman Index-0.32

Instability Index55.21

Aliphatic Index 38.48

Aromaticity 0.1212

Extinction Coeff. Reduced 5960.00

Extinction Coeff. Oxidized 6335.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1619.57

LogP -18.89

H-bond Donors 65.0

H-bond Acceptors 58.0

Rotatable Bonds 124.0

Heavy Atoms 262.0

Ring Count 5.0

Amide Bonds 34.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0239538 VERIFIED: YES

Provenance & Taxonomy

OrganismCentruroides tecomanus [Animal]

Structure & Mods

Configdisulfide-stabilized linear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Disulfide3-22; 8-27; 12-29

Bio-Activity Profile

Function

Toxin Ion channel blocker Potassium channel blocker

TargetKv1.2/KCNA2

Activity0.0036 μM

MethodIC50

RECORD: Rec_0377745 VERIFIED: YES