Peptide Database

Peptide NamePotassium channel toxin alpha-KTx 1.5

Function Ontology

Annotation / Sequence feature ▸ Nuclear export signal

Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Host defense activity

Membrane / Ion-channel modulation ▸ Ion channel inhibition

Membrane / Ion-channel modulation ▸ Potassium channel modulation ▸ Potassium channel inhibitor

Venom / Toxin ▸ General toxin ▸ Toxin

Venom / Toxin ▸ Toxin

Standard StatusStandard

Sequence Length37 amino acids

Chemical FormulaC177H280N52O50S8

DescriptionStandard

        QFTDVKCTGSKQCWPVCKQMFGKPNGKCMNGKCRCYS
    

Molecular Weight4192.96 Da

Isoelectric Point (pI)9.27

Net Charge (pH 7.0)5.69

Net Charge (pH 7.4) 5.39

Charge Density (pH 7.0) 0.1539

GRAVY Index-0.71

Hydrophobic Moment 0.44

Boman Index-0.17

Instability Index27.54

Aliphatic Index 15.68

Aromaticity 0.1081

Extinction Coeff. Reduced 6990.00

Extinction Coeff. Oxidized 7365.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1681.05

LogP -20.25

H-bond Donors 63.0

H-bond Acceptors 64.0

Rotatable Bonds 140.0

Heavy Atoms 287.0

Ring Count 7.0

Amide Bonds 41.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0186375 VERIFIED: YES

Provenance & Taxonomy

OrganismMesobuthus martensii [Animal]

FamilyPotassium channel inhibitor family

Tax ID34649; 0

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermPyroglutamate

Disulfide7-28; 13-33; 17-35

Bio-Activity Profile

Function

Toxin Venom Potassium channel inhibitor family Ion channel inhibitor Pathogenesis-associated Host defense