Peptide Database

Peptide NameSLAY-screened peptide P2121

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length21 amino acids

Chemical FormulaC112H179N33O29S

DescriptionStandard

        PPRMTNLNEYPVSVHPLRIHL
    

Molecular Weight2483.89 Da

Isoelectric Point (pI)9.18

Net Charge (pH 7.0)1.13

Net Charge (pH 7.4) 0.97

Charge Density (pH 7.0) 0.0540

GRAVY Index-0.42

Hydrophobic Moment 0.28

Boman Index-0.01

Instability Index35.30

Aliphatic Index 101.90

Aromaticity 0.0476

Extinction Coeff. Reduced 1490.00

Extinction Coeff. Oxidized 1490.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 970.29

LogP -7.32

H-bond Donors 33.0

H-bond Acceptors 33.0

Rotatable Bonds 74.0

Heavy Atoms 175.0

Ring Count 7.0

Amide Bonds 22.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0221157 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/