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MYP_047575
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Basic Information
Pleurain-D1 (Frogs,amphibians,animals)
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Membrane / Ion-channel modulation ▸ Calcium channel modulation ▸ Calcium channel inhibitor
Standard
23 amino acids
C117H197N27O27S2
Standard
Sequence
FLSGILKLAFKIPSVLCAVLKNC
Physicochemical Analysis
2478.11 Da
9.39
2.74
2.50
0.1190
1.38
0.56
0.41
-1.18
152.61
0.0870
0.00
125.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
856.34
-3.53
31.0
32.0
82.0
173.0
3.0
23.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0266624 VERIFIED: YES
Provenance & Taxonomy
Rana pleuraden [Animal]
Brevinin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative
Bacillus subtilis
50 μg/mL
MIC
PMID19028675 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/19028675/
RECORD: Rec_0276970 VERIFIED: YES
Provenance & Taxonomy
Babina pleuraden [Animal]
Brevinin
Structure & Mods
DNA-encoded linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
RECORD: Rec_0305083 VERIFIED: YES
Provenance & Taxonomy
Yunnan pond [Animal]
33208
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
PMID19028675 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/19028675/
RECORD: Rec_0312120 VERIFIED: NO
Provenance & Taxonomy
Rana pleuraden [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antioxidant
RECORD: Rec_0326836 VERIFIED: YES
Provenance & Taxonomy
Nidirana pleuraden [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Staphylococcus aureus
12.5 μg/mL
MIC
PMID19028675 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/19028675/
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