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MYP_047571
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Basic Information
Eval418-FH5
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antiviral
Antiviral ▸ Anti-Herpesvirus ▸ Anti-HSV
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
13 amino acids
C85H117N25O15
Standard
Sequence
LWHHIWHTVHHLI
Physicochemical Analysis
1729.00 Da
7.16
0.20
-0.26
0.0151
0.18
0.50
0.43
91.88
142.31
0.1538
11000.00
11000.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
607.73
0.71
22.0
20.0
49.0
125.0
9.0
12.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0002900 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Antiviral Cytotoxic
Vero cells
106
CC50
PaperPubMed PMID: 29290802 PMID29290802 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29290802/
RECORD: Rec_0022059 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Synthetic peptide
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antiviral
inhibition of viral attachment in Vero cells
0.67 μg/mL
IC50
Mammalian: 5.5 h; Yeast: 3 min; E. coli: 2 min
PaperHistidine-rich Modification of a Scorpion-derived Peptide Improves Bioavailability and Inhibitory Activity against HSV-1. | Zeng Z, Zhang R, Hong W, Cheng Y, Wang H, Lang Y, Ji Z, Wu Y, Li W, Xie Y, Cao Z. | Theranostics. 2018 Jan 1;8(1):199-211. | DOI:10.7150/thno.21425 | PMID:29290802 PMID29290802 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29290802/
RECORD: Rec_0050669 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Protein-derived synthetic peptide
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antiviral Anti-HSV Entry inhibition
HSV-1 | Vero cells
0.4974 μM
IC50
Mammalian: 5.5 h; Yeast: 3 min; E. coli: 2 min
PaperHistidine-rich Modification of a Scorpion-derived Peptide Improves Bioavailability and Inhibitory Activity against HSV-1. | Zeng Z, Zhang R, Hong W, Cheng Y, Wang H, Lang Y, Ji Z, Wu Y, Li W, Xie Y, Cao Z. | Theranostics. 2018 Jan 1;8(1):199-211. | DOI:10.7150/thno.21425 | PMID:29290802 PMID29290802 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29290802/
RECORD: Rec_0067487 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Antiviral
inhibition of viral attachment in Vero cells
0.67 μg/mL
IC50
PaperPubMed PMID: 29290802 PMID29290802 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29290802/
RECORD: Rec_0101126 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Antiviral
Herpes simplex virus type 1(HSV-1): inhibition of viral inactivation in Vero cells
0.86 μg/mL
IC50
PaperPubMed PMID: 29290802 PMID29290802 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29290802/
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