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MYP_047551
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Basic Information
Pancreatic polypeptide
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antibiotic activity
Antimicrobial ▸ Antifungal
Antimicrobial ▸ Antifungal ▸ Fungicidal activity
Antiparasitic ▸ Anti-Leishmania ▸ Antileishmanial
Antiparasitic ▸ General antiparasitic ▸ Antiparasitic
Hormonal / Endocrine ▸ Hormone peptide
Neurological / Signaling ▸ Neuromodulation
Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide
Neurological / Signaling ▸ Neuropeptide Y family
Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic
Standard
36 amino acids
C190H292N52O58S
Standard
Sequence
YPPKPESPGEDASPEEMNKYLTALRHYINLVTRQRY
Physicochemical Analysis
4264.73 Da
6.77
-0.15
-0.42
-0.0041
-1.21
0.71
-0.22
98.51
56.94
0.1111
5960.00
5960.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1781.90
-16.33
60.0
60.0
133.0
301.0
10.0
38.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0321957 VERIFIED: YES
Provenance & Taxonomy
Phyllomedusa bicolor [Animal]
Structure & Mods
DNA-encoded linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
RECORD: Rec_0323445 VERIFIED: YES
Provenance & Taxonomy
Phyllomedusa bicolor [Animal]
8393
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antifungal Antiparasitic
C. neoJbrmans, Candida albicans
25 μg/mL
MIC
PaperSkin peptide tyrosine-tyrosine, a member of the pancreatic polypeptide family: isolation, structure, synthesis, and endocrine activity.
RECORD: Rec_0329551 VERIFIED: YES
Provenance & Taxonomy
Phyllomedusa bicolor [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal
Escherichia coli
10 μg/mL
MIC
PMID7937944;8601432 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/7937944/
RECORD: Rec_0336417 VERIFIED: YES
Provenance & Taxonomy
Phyllomedusa bicolor [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal
Tricophyton rubrum
15 μg/mL
MIC
PMID7937944;8601432 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/7937944/
RECORD: Rec_0362969 VERIFIED: YES
Provenance & Taxonomy
Phyllomedusa bicolor [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal
Arthroderma simii
10 μg/mL
MIC
PMID7937944;8601432 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/7937944/
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