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MYP_047430
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Basic Information
Covid_extented_1
Antimicrobial
Antiviral
Antiviral ▸ Anti-Coronavirus ▸ Anti-SARS-CoV-2
Enzyme modulation ▸ Enzyme inhibition ▸ Infection inhibition
Membrane / Ion-channel modulation ▸ Sodium channel modulation ▸ Sodium channel inhibitor
Standard
32 amino acids
C181H253N45O48S
Standard
Sequence
RFDGKGLGIYQYMEEIEHAASRFAYFFYQHLA
Physicochemical Analysis
3859.28 Da
6.03
-1.06
-1.38
-0.0332
-0.33
0.60
0.09
60.75
61.25
0.2500
5960.00
5960.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1509.13
-8.72
53.0
50.0
124.0
275.0
10.0
33.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0041884 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
all-D amino-acid peptide [D]
Acylation
Amidation
Bio-Activity Profile
Antimicrobial Anti-SARS-CoV-2
SARS-CoV-2 variants B
PMID34624194 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/34624194/
RECORD: Rec_0062710 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
all-D amino-acid peptide [D]
Acylation
Amidation
Bio-Activity Profile
Antimicrobial Anti-SARS-CoV-2
Virus
PMID34624194 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/34624194/
RECORD: Rec_0066575 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Protein-derived synthetic peptide
32630
Structure & Mods
linear peptide [Linear]
all-D amino-acid peptide [D]
Acylation
Amidation
Acylation
Bio-Activity Profile
Antiviral Anti-SARS-CoV-2 Infection inhibition
SARS-CoV-2 | Vero cells
5.76±1.65 μM
IC50
Mammalian: 1 h; Yeast: 2 min; E. coli: 2 min
PaperComputational Design of Potent D-Peptide Inhibitors of SARS-CoV-2. | Valiente PA, Wen H, Nim S, Lee J, Kim HJ, Kim J, Perez-Riba A, Paudel YP, Hwang I, Kim KD, Kim S, Kim PM. | J Med Chem. 2021 Oct 28;64(20):14955-14967. | DOI:10.1021/acs.jmedchem.1c00655 | PMID:34624194 PMID34624194 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/34624194/
RECORD: Rec_0173674 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Protein-derived synthetic peptide
32630
Structure & Mods
linear peptide [Linear]
all-D amino-acid peptide [D]
Acylation
Amidation
Acylation
Bio-Activity Profile
Antiviral Anti-SARS-CoV-2 Infection inhibition
SARS-CoV-2 variants B.1.1.7 | Vero cells
5.57±4.04 μM
IC50
Mammalian: 1 h; Yeast: 2 min; E. coli: 2 min
PaperComputational Design of Potent D-Peptide Inhibitors of SARS-CoV-2. | Valiente PA, Wen H, Nim S, Lee J, Kim HJ, Kim J, Perez-Riba A, Paudel YP, Hwang I, Kim KD, Kim S, Kim PM. | J Med Chem. 2021 Oct 28;64(20):14955-14967. | DOI:10.1021/acs.jmedchem.1c00655 | PMID:34624194 PMID34624194 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/34624194/
RECORD: Rec_0247642 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
all-D amino-acid peptide [D]
Acylation
Amidation
Bio-Activity Profile
Antimicrobial Anti-SARS-CoV-2
SARS-CoV-2:inhibition of infection in Vero cells
5.76±1.65 μM
IC50
PMID34624194 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/34624194/
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