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MYP_047351
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Basic Information
LL-37 (17-29) [R23L,I24L,D26K,F27L]-Ac
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
13 amino acids
C79H143N23O15
Standard
Sequence
FKRIVQLLKKLLR
Physicochemical Analysis
1655.13 Da
12.00
4.76
4.55
0.3659
0.19
0.95
-0.19
17.97
172.31
0.0769
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
657.47
-1.48
24.0
20.0
61.0
117.0
1.0
13.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0034721 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Acetylation
Amidation
Bio-Activity Profile
Antimicrobial Anticancer Cytotoxic
PaperCationic amphipathic peptide analogs of cathelicidin LL-37 as a probe in the development of antimicrobial/anticancer agents. J Pept Sci. 2020;26:e3254. doi: 10.1002/psc.3254. PMID: 32567085. PMID32567085 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/32567085/
RECORD: Rec_0165342 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Acetylation
Amidation
Bio-Activity Profile
Antimicrobial Anticancer Hemolytic
Human erythrocytes
185 μg/mL
HC50
PaperCationic amphipathic peptide analogs of cathelicidin LL-37 as a probe in the development of antimicrobial/anticancer agents. J Pept Sci. 2020;26:e3254. doi: 10.1002/psc.3254. PMID: 32567085. PMID32567085 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/32567085/
RECORD: Rec_0171778 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Anticancer
Tumor cells: A549
9.8 μg/mL
IC50
PaperCationic amphipathic peptide analogs of cathelicidin LL-37 as a probe in the development of antimicrobial/anticancer agents. J Pept Sci. 2020;26:e3254. doi: 10.1002/psc.3254. PMID: 32567085. PMID32567085 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/32567085/
RECORD: Rec_0323054 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Acetylation
Amidation
Bio-Activity Profile
Antimicrobial Anticancer
Tumor cells: A549
9.8 μg/mL
IC50
PaperCationic amphipathic peptide analogs of cathelicidin LL-37 as a probe in the development of antimicrobial/anticancer agents. J Pept Sci. 2020;26:e3254. doi: 10.1002/psc.3254. PMID: 32567085. PMID32567085 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/32567085/
RECORD: Rec_0328331 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Anticancer
Tumor cells: A549
12.8 μg/mL
IC50
PaperCationic amphipathic peptide analogs of cathelicidin LL-37 as a probe in the development of antimicrobial/anticancer agents. J Pept Sci. 2020;26:e3254. doi: 10.1002/psc.3254. PMID: 32567085. PMID32567085 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/32567085/
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