Peptide Database

Peptide NameSLAY-screened peptide P4228

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length20 amino acids

Chemical FormulaC96H166N40O26

DescriptionStandard

        TRRARRTHRVHAAVLNSPTP
    

Molecular Weight2296.60 Da

Isoelectric Point (pI)12.00

Net Charge (pH 7.0)4.57

Net Charge (pH 7.4) 4.28

Charge Density (pH 7.0) 0.2286

GRAVY Index-1.04

Hydrophobic Moment 0.67

Boman Index-0.46

Instability Index88.75

Aliphatic Index 63.50

Aromaticity 0.0000

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 0.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1089.51

LogP -14.70

H-bond Donors 41.0

H-bond Acceptors 33.0

Rotatable Bonds 71.0

Heavy Atoms 162.0

Ring Count 4.0

Amide Bonds 20.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0030249 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/