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MYP_047250
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Basic Information
LfcinB
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antiviral
Cardiovascular ▸ Blood pressure regulation ▸ Antihypertensive
Membrane / Ion-channel modulation ▸ Calcium channel modulation ▸ Calcium channel inhibitor
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
12 amino acids
C80H125N27O14S2
Standard
Sequence
FKCRRWQWRMKK
Physicochemical Analysis
1753.15 Da
11.74
5.75
5.53
0.4789
-1.94
0.51
-0.77
92.11
0.00
0.2500
11000.00
11000.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
721.85
-3.45
29.0
22.0
60.0
123.0
5.0
12.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0369805 VERIFIED: YES
Provenance & Taxonomy
Bovine lactoferrin [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Anticancer
Ramos
10 μM
IC50
PaperPubMed PMID: 19527490 PMID19527490 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/19527490/
RECORD: Rec_0373753 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Transferrin
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
S. aureusATCC 25923
200 μM
MIC
PMID28613262 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28613262/
RECORD: Rec_0394554 VERIFIED: YES
Provenance & Taxonomy
Bos taurus [Animal]
Lactoferrin-derived peptide
9913
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Anticancer Cytotoxic
HT-29
>160 μM
IC50
PMID21453492;23533710 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21453492/
RECORD: Rec_0400334 VERIFIED: YES
Provenance & Taxonomy
Bos taurus [Animal]
Bovine milk
9913
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Antiviral Antihypertensive
AZ-97
100 μg/mL
Inhibition
PMID23533710 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23533710/
RECORD: Rec_0401102 VERIFIED: NO
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Anticancer
PaperAntiCP 2.0: an updated model for predicting anticancer peptides (benchmark provenance; exact sequence-level experiment paper unresolved here) | https://pubmed.ncbi.nlm.nih.gov/32770192/
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