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MYP_047250
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Basic Information
LfcinB
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antiviral
Cardiovascular ▸ Blood pressure regulation ▸ Antihypertensive
Membrane / Ion-channel modulation ▸ Calcium channel modulation ▸ Calcium channel inhibitor
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
12 amino acids
C80H125N27O14S2
Standard
Sequence
FKCRRWQWRMKK
Physicochemical Analysis
1753.15 Da
11.74
5.75
5.53
0.4789
-1.94
0.51
-0.77
92.11
0.00
0.2500
11000.00
11000.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
721.85
-3.45
29.0
22.0
60.0
123.0
5.0
12.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0177355 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Anticancer Antiviral Antihypertensive Antimicrobial Antioxidant
PaperCancerPPD: a database of anticancer peptides and proteins PMID25270878 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25270878/
RECORD: Rec_0196381 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Transferrin
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Escherichia coli ATCC 25922(MIC=200microM),(MBC=200microM); S. aureusATCC 25923(MIC=>200microM),(MBC=>200microM)
200 μM
MBC
PMID28613262 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28613262/
RECORD: Rec_0204281 VERIFIED: YES
Provenance & Taxonomy
Bovine lactoferrin [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Anticancer
Kelly
141±3 μM
IC50
PaperPubMed PMID: 19527490 PMID19527490 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/19527490/
RECORD: Rec_0235250 VERIFIED: YES
Provenance & Taxonomy
Escherichia coli [Bacterium]
562.0
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial
PaperHuertas N. J., Rivera Monroy Z. J., Fierro Medina R., Garc¨ªa Casta?eda J. E.. Antimicrobial activity of truncated and polyvalent peptides derived from the FKCRRWQWRMKKGLA sequence against Escherichia coli ATCC 25922 and Staphylococcus aureus ATCC 25923. Molecules, 22, Article No 987, 2017.
RECORD: Rec_0256112 VERIFIED: YES
Provenance & Taxonomy
Bos taurus [Animal]
Lactoferrin-derived peptide
9913
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Anticancer
U-266
55 μM
IC50
PMID19527490;23533710 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/19527490/
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