Peptide Database

Peptide NameMyotoxin II (105-117)[Y3,6W][Y5K,P9W,C11A], PEM-2 [W5K,A9W]

Function Ontology

Anticancer

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length13 amino acids

Chemical FormulaC90H143N25O14

DescriptionStandard

        KKWRKWLKWLAKK
    

Molecular Weight1799.26 Da

Isoelectric Point (pI)11.43

Net Charge (pH 7.0)6.75

Net Charge (pH 7.4) 6.54

Charge Density (pH 7.0) 0.5195

GRAVY Index-1.63

Hydrophobic Moment 0.71

Boman Index-0.49

Instability Index21.68

Aliphatic Index 67.69

Aromaticity 0.2308

Extinction Coeff. Reduced 16500.00

Extinction Coeff. Oxidized 16500.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 677.91

LogP 0.54

H-bond Donors 26.0

H-bond Acceptors 21.0

Rotatable Bonds 63.0

Heavy Atoms 129.0

Ring Count 6.0

Amide Bonds 12.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0327830 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilyDefensin

Tax ID32630

Structure & Mods

Configsynthetic linear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antibacterial Anti-Gram-negative

TargetEscherichia coli ST131

Activity2 μM

MethodMIC

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