Peptide Database

Peptide NameGBVA10-1(L9K)

Function Ontology

Antimicrobial

Antiviral

Antiviral ▸ Anti-Hepatitis virus ▸ Anti-HCV

Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition

Standard StatusStandard

Sequence Length18 amino acids

Chemical FormulaC106H173N33O22S

DescriptionStandard

        CWVRLGRYKLRRLKTPFT
    

Molecular Weight2293.78 Da

Isoelectric Point (pI)11.57

Net Charge (pH 7.0)5.75

Net Charge (pH 7.4) 5.53

Charge Density (pH 7.0) 0.3193

GRAVY Index-0.58

Hydrophobic Moment 0.71

Boman Index-0.32

Instability Index57.48

Aliphatic Index 81.11

Aromaticity 0.1667

Extinction Coeff. Reduced 6990.00

Extinction Coeff. Oxidized 6990.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 925.35

LogP -5.51

H-bond Donors 37.0

H-bond Acceptors 29.0

Rotatable Bonds 74.0

Heavy Atoms 162.0

Ring Count 5.0

Amide Bonds 17.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0389172 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilyProtein-derived synthetic peptide

Tax ID32630

Structure & Mods

Configsynthetic linear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermNone

Bio-Activity Profile

Function

Antiviral Anti-HCV Entry inhibition

TargetHepatitis C virus(Jc1-Luc HCVcc) | Huh7.5.1 cells

Activity20 μM

MethodIC50

Half-LifeMammalian: 1.2 h; Yeast: >20 h; E. coli: >10 h

PaperScreening and rational design of hepatitis C virus entry inhibitory peptides derived from GB virus A NS5A. | Liu X, Huang Y, Cheng M, Pan L, Si Y, Li G, Niu Y, Zhao L, Zhao J, Li X, Chen Y, Yang W. | J Virol. 2013 Feb;87(3):1649-57. | DOI:10.1128/JVI.02201-12 | PMID:23175359 PMID23175359 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23175359/

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