Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Standard StatusStandard

Sequence Length509 amino acids

Chemical FormulaC2565H3992N652O735S15

DescriptionStandard

        MRTKQVPVLGACFLLWSLYIASSQTVYPGIKARITQRALDYGLQVGMEILEQLAKEIVIPDLNGSESLKFLKIDYVKYNFSNIKINAFSFPNTSLAFVPGVGIRALSNHGTANISTNWDVKAPLFQDSGAADLFLSGIYFTGIIVFTRNDFGHPALELQDCHVQVSHARVSFSGGLSVLYNSFAEPMEKPILKNLNEMVSLCPIAISQVEEFNVNISALEVLTKIDNYTVLDCSLISPPEVTENHLDFHLKGAFYPLESLVDPPFTPAPFELPESRDSMLYIGVSEYFFKSASFAHFVSGALGTVLSTREISNYFNQNAQGIGSVLSKIAEIYILSQPFMLQIMATGPPVVNLHPNNFSLELPAAVIMLTQPENSTIQPIVSMDFVASTSVGLAILGQKLICSLSLNRFRLSLPENSPRDIKVVRFENILSSILHFGVLPLANTKLQQGFPLPNPYNISFVNSDIEVLEGFLLISTDVAHETSSKQQPNLHSWGHLNMVHGPRKKQPIH
    

Molecular Weight56204.04 Da

Isoelectric Point (pI)5.78

Net Charge (pH 7.0)-9.27

Net Charge (pH 7.4) -10.37

Charge Density (pH 7.0) -0.0182

GRAVY Index0.16

Hydrophobic Moment 0.68

Boman Index0.18

Instability Index36.38

Aliphatic Index 103.60

Aromaticity 0.0963

Extinction Coeff. Reduced 37360.00

Extinction Coeff. Oxidized 37610.00

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Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0142039 VERIFIED: NO

Provenance & Taxonomy

OrganismRattus norvegicus [Animal]

FamilyBPI/LBP

Tax ID10116

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Anti-Gram-negative Cytotoxic Non-hemolytic

TargetGram-negative bacteria