Peptide Database

Peptide NameSLAY-screened peptide P5863

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length20 amino acids

Chemical FormulaC108H171N29O29

DescriptionStandard

        PPHLSVVVIFSEERRDFIAK
    

Molecular Weight2339.69 Da

Isoelectric Point (pI)7.18

Net Charge (pH 7.0)0.05

Net Charge (pH 7.4) -0.06

Charge Density (pH 7.0) 0.0026

GRAVY Index0.07

Hydrophobic Moment 0.33

Boman Index0.03

Instability Index69.93

Aliphatic Index 107.00

Aromaticity 0.1000

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 0.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 924.30

LogP -6.04

H-bond Donors 33.0

H-bond Acceptors 30.0

Rotatable Bonds 75.0

Heavy Atoms 166.0

Ring Count 5.0

Amide Bonds 19.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0078689 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antibacterial Enzyme inhibitory ACE inhibitory

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/