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MYP_046906
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Basic Information
Kasseptin 1Mb
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytolysis / cell lysis ▸ Cytolytic activity
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Toxic
Venom / Toxin ▸ General toxin ▸ Toxicity
Standard
20 amino acids
C97H154N24O23
Standard
Sequence
FFGAIAAALPHVISAIKNAL
Physicochemical Analysis
2024.41 Da
8.76
0.85
0.59
0.0423
1.42
0.51
0.56
10.64
142.00
0.1000
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
725.45
-3.80
24.0
25.0
62.0
144.0
4.0
20.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0192131 VERIFIED: YES
Provenance & Taxonomy
Kassina maculata [Animal]
Structure & Mods
topology not specified [Not included yet]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive
Staphylococcus aureus
PaperPubMed PMID: 19427345 PMID19427345 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/19427345/
RECORD: Rec_0203608 VERIFIED: YES
Provenance & Taxonomy
Kassina maculata [Animal]
Structure & Mods
topology not specified [Not included yet]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Hemolytic
horse erythrocytes
PaperPubMed PMID: 19427345 PMID19427345 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/19427345/
RECORD: Rec_0205058 VERIFIED: YES
Provenance & Taxonomy
Kassina maculata [Animal]
Kasseptin
Structure & Mods
ribosomal mature linear peptide [Linear]
Gene-encoded natural peptide composed of standard L-amino acids [L]
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive
Staphylococcus aureus
16.0 μM
MIC
PaperL. Wang et al. / Peptides 30 (2009) 1428-1433. A family of kassinatuerin-2 related peptides from the skin secretion of the African hyperoliid frog, Kassina maculata Evidence URLhttps://www.uniprot.org/uniprotkb/C7C1K9/entry
RECORD: Rec_0210895 VERIFIED: YES
Provenance & Taxonomy
African hyperoliid [Animal]
33208
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
PMID19427345 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/19427345/
RECORD: Rec_0220636 VERIFIED: YES
Provenance & Taxonomy
Kassina maculata [Animal]
Structure & Mods
DNA-encoded linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
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