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MYP_046897
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Basic Information
Protamine (19-32), Pr-3
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antifungal
Antiparasitic ▸ Anti-Leishmania ▸ Antileishmanial
Antiparasitic ▸ Antiprotozoal
Antiparasitic ▸ General antiparasitic ▸ Antiparasitic
Delivery / Targeting ▸ Cell penetration ▸ Cell-penetrating peptide
Delivery / Targeting ▸ Drug delivery vehicle
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
14 amino acids
C72H142N44O16
Standard
Sequence
VSRRRRRRGGRRRR
Physicochemical Analysis
1880.18 Da
12.00
9.73
9.52
0.6953
-3.03
0.52
-1.67
353.11
20.71
0.0000
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1080.85
-15.76
46.0
26.0
69.0
132.0
0.0
13.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0012436 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antiparasitic Antiprotozoal Antifungal
Leishmania major promastigote
100 μg/mL
EC50
PMID21262294;27915244 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21262294/
RECORD: Rec_0014215 VERIFIED: YES
Provenance & Taxonomy
Protein derived [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Anticancer Cytotoxic
PMID25003794 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25003794/
RECORD: Rec_0021789 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antiparasitic Antiprotozoal Antifungal
Candida tropicalis IFM 46862
2.5 μM
MIC
PMID21262294;27915244 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21262294/
RECORD: Rec_0026916 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Cytotoxic
Human dendritic cells
22.28±0.37 μg/mL
Cytotoxicity
PMID21262294;27915244 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21262294/
RECORD: Rec_0038527 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
low
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Sulfhydrylation
None
Sulfhydrylation
Bio-Activity Profile
Cell-penetrating peptide Cargo delivery
PMID23863452 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23863452/
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