Peptide Database

Peptide NameIslet amyloid polypeptide

Function Ontology

Hormonal / Endocrine ▸ Hormone peptide

Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide

Regulatory peptide ▸ Biological regulation

Standard StatusStandard

Sequence Length33 amino acids

Chemical FormulaC150H233N43O47S2

DescriptionStandard

        CNTVTCATQRLANFLIHSSNNFGAIFSPPSVGS
    

Molecular Weight3454.84 Da

Isoelectric Point (pI)8.08

Net Charge (pH 7.0)0.83

Net Charge (pH 7.4) 0.55

Charge Density (pH 7.0) 0.0251

GRAVY Index0.26

Hydrophobic Moment 0.48

Boman Index0.19

Instability Index22.58

Aliphatic Index 73.94

Aromaticity 0.0909

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 125.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1444.81

LogP -20.57

H-bond Donors 51.0

H-bond Acceptors 51.0

Rotatable Bonds 106.0

Heavy Atoms 242.0

Ring Count 6.0

Amide Bonds 37.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0005259 VERIFIED: YES

Provenance & Taxonomy

OrganismOryctolagus cuniculus [Animal]

FamilyIslet amyloid polypeptide

Tax ID9986

Structure & Mods

Configdisulfide-constrained peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

Disulfide1-6

Bio-Activity Profile

Function

Hormone Endocrine Metabolic regulation Physiological regulation

Half-LifeMammalian: 1.2 hour; Yeast: >20 hour; E. coli: >10 hour

RECORD: Rec_0152576 VERIFIED: NO

Provenance & Taxonomy

OrganismOryctolagus cuniculus [Animal]

FamilyCalcitonin

Tax ID9986

Structure & Mods

Configdisulfide-constrained cyclic peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

Disulfide1-6

Bio-Activity Profile

Function

Hormone Calcium-regulatory peptide

RECORD: Rec_0157295 VERIFIED: YES

Provenance & Taxonomy

Organismnot reported [other]

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Neuropeptide

Paper数据库级溯源文献：Wang Y, Wang M, Yin S, et al. NeuroPep: a comprehensive resource of neuropeptides. Database (Oxford). 2015:bav038. PMID 25931458; Bin Y, Zhang W, Tang W, et al. Prediction of Neuropeptides from Sequence Information Using Ensemble Classifier and Hybrid Features. J Proteome Res. 2020;19(9):3732-3740. PMID 32786686. PMID25931458;32786686 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25931458/