Peptide Database

Peptide NameNPP 1

Function Ontology

Hormonal / Endocrine ▸ Hormone peptide

Neurological / Signaling ▸ Neuromodulation

Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide

Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide precursor

Standard StatusStandard

Sequence Length80 amino acids

Chemical FormulaC389H609N103O126S4

DescriptionStandard

        QCWENPRCHDLSSENNLLECIQLCRSDLTTKSPIFPVKVHLQPPSPSDSDSPPLYLPLSLLSPSSPLYPTEQQNSVSPQA
    

Molecular Weight8872.87 Da

Isoelectric Point (pI)4.74

Net Charge (pH 7.0)-4.09

Net Charge (pH 7.4) -4.47

Charge Density (pH 7.0) -0.0512

GRAVY Index-0.53

Hydrophobic Moment 0.38

Boman Index-0.02

Instability Index106.14

Aliphatic Index 80.38

Aromaticity 0.0500

Extinction Coeff. Reduced 8480.00

Extinction Coeff. Oxidized 8730.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 3610.61

LogP -42.30

H-bond Donors 120.0

H-bond Acceptors 128.0

Rotatable Bonds 272.0

Heavy Atoms 622.0

Ring Count 20.0

Amide Bonds 89.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0166792 VERIFIED: YES

Provenance & Taxonomy

OrganismOncorhynchus mykiss [Animal]

FamilyNPP

Tax ID8022

Structure & Mods

Configlinear peptide with reported disulfide constraint [Linear]

Chiralitynoncanonical stereochemical modification [Modified]

N-TermPyroglutamate

Disulfide2-24; 8-20

Bio-Activity Profile

Function

Hormone Endocrine Neuropeptide Neuromodulator

Half-LifeMammalian: 0.8 hour; Yeast: 10 min; E. coli: >10 hour

RECORD: Rec_0186455 VERIFIED: NO

Provenance & Taxonomy

OrganismOncorhynchus mykiss [Animal]

FamilyPOMC

Tax ID8022

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermPyroglutamate

Bio-Activity Profile

Function

Hormone precursor Neuropeptide precursor

RECORD: Rec_0207294 VERIFIED: YES

Provenance & Taxonomy

Organismnot reported [other]

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Neuropeptide

Paper数据库级溯源文献：Wang Y, Wang M, Yin S, et al. NeuroPep: a comprehensive resource of neuropeptides. Database (Oxford). 2015:bav038. PMID 25931458; Bin Y, Zhang W, Tang W, et al. Prediction of Neuropeptides from Sequence Information Using Ensemble Classifier and Hybrid Features. J Proteome Res. 2020;19(9):3732-3740. PMID 32786686. PMID25931458;32786686 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25931458/