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MYP_046802
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Basic Information
Brevinin-1BYa
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Antimicrobial ▸ Antifungal ▸ Anti-Candida
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytolysis / cell lysis ▸ Cytolytic activity
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
24 amino acids
C126H206N28O27S2
Standard
Sequence
FLPILASLAAKFGPKLFCLVTKKC
Physicochemical Analysis
2609.28 Da
9.70
3.74
3.50
0.1557
1.07
0.49
0.34
26.58
122.08
0.1250
0.00
125.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
859.58
-2.34
31.0
33.0
84.0
183.0
5.0
23.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0362465 VERIFIED: YES
Provenance & Taxonomy
Rana boylii [Animal]
Brevinin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
18-24
Bio-Activity Profile
Antimicrobial Antifungal Anticancer
C. tropicalis V1757, V3117, B51a/5
5 μM
MIC
PaperBrevinin-1BYa: a naturally occurring peptide from frog skin with broad-spectrum antibacterial and antifungal properties
RECORD: Rec_0371199 VERIFIED: YES
Provenance & Taxonomy
Rana boylii [Animal]
Brevinin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
18-24
Bio-Activity Profile
Antimicrobial Antifungal Anticancer
opportunistic yeast pathogens such as Candida albicans ATCC 90029, V2414, V3577
3-5 μM
MIC
PaperBrevinin-1BYa: a naturally occurring peptide from frog skin with broad-spectrum antibacterial and antifungal properties
RECORD: Rec_0385029 VERIFIED: YES
Provenance & Taxonomy
Rana boylii [Animal]
Brevinin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
18-24
Bio-Activity Profile
Antimicrobial Antifungal Anticancer
also Gram- Escherichia coli ATCC 25922
17-20 μM
MIC
PaperBrevinin-1BYa: a naturally occurring peptide from frog skin with broad-spectrum antibacterial and antifungal properties
RECORD: Rec_0402440 VERIFIED: YES
Provenance & Taxonomy
Rana boylii [Animal]
Brevinin
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
18-24
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Hemolytic
Candida albicans
3 μM
MIC
RECORD: Rec_0409382 VERIFIED: YES
Provenance & Taxonomy
Rana boylii [Animal]
Brevinin
Structure & Mods
Linear peptide with a single intramolecular disulfide-stabilized loop [Linear]
Gene-encoded natural peptide composed of standard L-amino acids [L]
18-24
Bio-Activity Profile
Hemolytic Cytolytic
Erythrocytes
10.0 μM
HC50
PaperT. Pal et al. / International Journal of Antimicrobial Agents 27 (2006) 525-529. Brevinin-1BYa: a naturally occurring peptide from frog skin with broad-spectrum antibacterial and antifungal properties Evidence URLhttps://www.uniprot.org/uniprotkb/P84111/entry
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