Peptide Database

Peptide NameSLAY-screened peptide P4135

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length19 amino acids

Chemical FormulaC86H136N22O26S

DescriptionStandard

        ASGVPNIVPVSSPVLHCSY
    

Molecular Weight1926.20 Da

Isoelectric Point (pI)6.77

Net Charge (pH 7.0)-0.13

Net Charge (pH 7.4) -0.38

Charge Density (pH 7.0) -0.0067

GRAVY Index0.68

Hydrophobic Moment 0.32

Boman Index0.36

Instability Index101.94

Aliphatic Index 107.37

Aromaticity 0.0526

Extinction Coeff. Reduced 1490.00

Extinction Coeff. Oxidized 1490.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 733.67

LogP -8.30

H-bond Donors 25.0

H-bond Acceptors 28.0

Rotatable Bonds 53.0

Heavy Atoms 135.0

Ring Count 5.0

Amide Bonds 19.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0161242 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/