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MYP_046778
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Basic Information
Odorranain-F1 (OdF1; Frogs, amphibians, animals)
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Standard
29 amino acids
C133H229N37O40S3
Standard
Sequence
GFMDTAKNAAKNVAVTLLDNLKCKITKAC
Physicochemical Analysis
3082.66 Da
9.24
2.74
2.50
0.0944
0.12
0.58
0.03
10.84
91.03
0.0345
0.00
125.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1272.78
-13.58
45.0
46.0
107.0
213.0
1.0
31.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0001990 VERIFIED: YES
Provenance & Taxonomy
Odorrana grahami [Animal]
Odorranain
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Cyclization
23-29
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal
Staphylococcus aureus
2.1 μg/mL
MIC
PaperAnti-infection peptidomics of amphibian skin. Mol Cell Proteomics. 2007 May;6(5):882-94. doi: 10.1074/mcp.M600334-MCP200. PMID: 17272268. PMID17272268 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/17272268/
RECORD: Rec_0009162 VERIFIED: NO
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal
PaperCAMP: Collection of sequences and structures of antimicrobial peptides PMID24265220 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24265220/
RECORD: Rec_0028371 VERIFIED: YES
Provenance & Taxonomy
Odorrana grahami [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
RECORD: Rec_0044928 VERIFIED: YES
Provenance & Taxonomy
Odorrana grahami [Animal]
Odorranain
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Cyclization
23-29
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal Hemolytic
PaperAnti-infection peptidomics of amphibian skin. Mol Cell Proteomics. 2007 May;6(5):882-94. doi: 10.1074/mcp.M600334-MCP200. PMID: 17272268. PMID17272268 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/17272268/
RECORD: Rec_0129474 VERIFIED: YES
Provenance & Taxonomy
Odorrana grahami [Animal]
Odorranain
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Cyclization
23-29
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal Hemolytic
rabbit red blood cells at 50 μg/ml
PaperAnti-infection peptidomics of amphibian skin. Mol Cell Proteomics. 2007 May;6(5):882-94. doi: 10.1074/mcp.M600334-MCP200. PMID: 17272268. PMID17272268 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/17272268/
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